Life & Beth follows the story of Beth, a woman whose life looks great on paper. She is successful as a wine distributor, has a long-term relationship with a successful guy, and lives in Manhattan. However, a sudden, unexpected incident forces Beth to engage with her past, leading her to re-evaluate her current existence and the choices that led her there. As she navigates her trauma and memories, Beth begins to reconnect with her teenage self and finds herself drawn to a simpler, more authentic life in her hometown. The series explores themes of grief, self-discovery, and the courage required to change one's trajectory, often blending poignant drama with Amy Schumer's signature comedic sensibility.