Mula sa Puso follows the life of Via Pereira, a wealthy heiress who becomes the target of her greedy aunt, Selina, and her cousin, Criselda. After her father is murdered, Via is forced to flee her life of luxury and navigate the harsh realities of the streets, where she meets Gabriel, a kind-hearted man who becomes her protector and eventual love interest. As she struggles to survive, she discovers the truth about her family's dark secrets and the depth of the betrayal she suffered. The series centers on Via's journey toward reclaiming her identity and seeking justice for her father's death. Along the way, she must confront the manipulative schemes of Selina, who will stop at nothing to secure the Pereira fortune. The drama explores themes of social class disparity, the resilience of the human spirit, and the enduring power of love amidst overwhelming adversity.