South Wind Knows follows the story of Fu Yunshen, a pharmaceutical researcher who travels to a remote, underdeveloped region to search for a medicinal herb. There, he meets Zhu Jiu, a compassionate surgeon on a medical mission. Despite their initial misunderstandings and clashing personalities, the two bond while working together to provide medical aid to the locals, eventually falling in love. However, their budding romance is cut short when Yunshen suffers a tragic accident that leaves him physically disabled and emotionally shattered, leading him to push Zhu Jiu away to protect her from his new reality. Years later, their paths cross again under different circumstances. Yunshen, now struggling with his trauma and family business conflicts, finds that Zhu Jiu has remained steadfast in her profession and her feelings. As they navigate the complexities of corporate intrigue, family secrets, and the lingering scars of the past, they must learn to confront their vulnerabilities and heal together. The series explores themes of resilience, the transformative power of love, and the courage required to move forward after life-altering adversity.